Ketamine Clinics in Missouri

Our directory tracks 3 verified, Google-listed ketamine and Spravato providers across Missouri, updated monthly from public business data.

Spravato (esketamine) is FDA-approved for treatment-resistant depression and is increasingly covered by major insurers in Missouri when REMS protocol criteria are met. IV ketamine remains off-label and is rarely covered.

Most Missouri clinics accept self-referral for IV ketamine, but Spravato typically requires a psychiatrist referral and documented treatment-resistant depression diagnosis.

IV infusions in Missouri generally range $400–$800 per session, with most protocols calling for 6 initial sessions plus periodic boosters. Spravato copays vary by insurance plan.

IV ketamine (racemic) is delivered as an infusion in-clinic and used off-label for depression, PTSD, and chronic pain. Spravato (esketamine) is an FDA-approved intranasal spray for treatment-resistant depression and is covered by REMS — both must be administered in-clinic.